Interestingly, Mathew et al. [21] in their elegant study had shown at least three different immunotypes of COVID-19, 1–3, depending on the cluster of differentiation of (CD)4+ cell, CD8+ cell, and B-cell, and plasmablasts activation/exhaustion, which was associated with different outcomes but also most likely with different levels of cytokines. The gene discussed is CD8A; the disease is COVID-19.