Analyses based on clinical specimens showed that AHNAK2 regulated the EMT via a TGF-β/Smad3 pathway in lung adenocarcinoma and a hypoxia inducible factor-1α/zinc finger E-box-binding homeobox 1 (HIF-1/ZEB1) pathway in clear cell renal cell carcinoma [10,16]. The gene discussed is HIF1A; the disease is lung adenocarcinoma.