NES and Familial prostate cancer: Because the HE of AHNAK2 correlated with a significantly higher proportion of S100A8/9 and nestin in the current study, several in vitro studies indicated that S100A8/9 activated MAPK pathway in breast, colon, and prostate cancer, and nestin activated PI3K phosphorylation in glioblastoma and embryogenesis [25,26].