EGFR activation during melanoma progression not only leads to the activation of various signaling pathways including PI3K/AKT and MAPK, but also promotes cell switching towards an invasive phenotype associated with loss of E-cadherin that favors release of cadherin-bound β-catenin; free β-catenin translocate to the nucleus and activate pro-invasive factors [108,109]. This evidence concerns the gene EGFR and melanoma.