EGFR and melanoma: In melanoma, as EGFR was shown to affect tumor cell functions from proliferation to differentiation as well as cell death, and as VEGF has been identified as a potent contributor to angiogenesis, tumor proliferation, and lymphangiogenesis, a first preclinical study was launched to evaluate the effect of erlotinib and bevacizumab in a human melanoma xenograft model.