Intriguingly, RIG-I-mediated interferon responses have been detected without viral or bacterial triggers in association with autoimmune diseases [86], such as relapsing–remitting multiple sclerosis, Rheumatoid arthritis, Sjögren’s syndrome, and systemic lupus erythematosus [87,88,89,90,91]. The gene discussed is RIGI; the disease is rheumatoid arthritis.