The gene expression profiling of bone marrow CD34+ cells confirmed higher BMI1 expression in CML patients than in healthy donors (p = 0.008), and this was associated with an increase in PKCδ mRNA expression (p = 0.02), while PKCε mRNA decreased (p = 0.004) (Figure 1A). Here, PRKCD is linked to chronic myelogenous leukemia, BCR-ABL1 positive.