LEP and metabolic dysfunction-associated steatohepatitis: A few NASH models based on genetic modifications have been described: the Zucker fatty rats (fa/fa), which bear spontaneous mutations for leptin receptor; the stroke-prone spontaneously hypertensive 5/Dmcr rats (SHRSP5/Dmcr); the Otsuka Long–Evans Tokushima fatty rats (OLETF) [17]; the Cx32 dominant-negative transgenic rats (Cx32ΔTg) [18]; and the Leptin mutant rats (LepDI14/DI14) [19].