By the use of shotgun proteomics, comparing the profile of grade I meningioma biopsies of male and female patients, a significant differential expression of several proteins was revealed between the two groups, with a higher abundance of cell-matrix organization genes as S100A4 in males, and thus suggesting that the protein was related to the higher cancer aggressiveness and poorer prognosis of patients [54]. This evidence concerns the gene S100A4 and cancer.