Indeed, four weeks of a high-fat diet or glucose intolerance has been associated with markedly increased expression of anti-angiogenic factors endostatin and angiostatin, increased oxidative stress and additional signaling abnormalities, which likely have a major effect in diminishing the angiogenic response to growth factors or cell therapy, or the angiogenic process in general in both animal models and in patients [64,65,66]. This evidence concerns the gene PLG and Glucose intolerance.