NEUROG3 and Hyperglycemia: A pancreatic β-cell-specific mutant KATP channel-expressing mice (with reduced responsiveness to ATP) exhibit pancreatic β-cell dedifferentiation in response to hyperglycemia, but when hyperglycemia is ameliorated by insulin administration to these mice, the number of Ngn3-positive cells decreases, and the number of insulin-positive cells increases [28].