Singh et al. indicated that obesity and oxidative stress are accompanied with increased NOV levels and inflammation associated with increased release of TNF- α and IL-6 and a decrease in HO-1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) [77]. The gene discussed is HMOX1; the disease is obesity due to melanocortin 4 receptor deficiency.