INS and Hyperglycemia: Furthermore, one randomized crossover trial in the U.S. [42] including 7 participants (age 43–67 years) demonstrated that consuming an extra 50 g of fat in the dinner meal was associated with more hyperglycemia (measured by AUC) during two 18 h continuous monitoring periods and led to an increased insulin requirement, compared to a lower fat meal (10 g), even when additional insulin was administered.