In 101 breast cancer patients, we have detected two mutations in CHECK2 (c.444+1G>A (n=1) and del5395 (exon 10–11 deletion) (n = 1)) and two mutations in PALB2 (c.509_510delGA (n = 1) and c.172_175delTTGT (n = 1)). This evidence concerns the gene PALB2 and breast carcinoma.