NME1 and lung carcinoma: NME2 is reported to be an inhibitor of cell motility and cell invasion [53,54,55,56,57], one study found enhanced metastasis of NME2-depleted lung cancer cells in zebrafish and in nude mice [58], and overexpression of NME2 in oral squamous carcinoma cells reduced their ability to form lung metastases [59], all of which suggest potentially a similar function to NME1. Furthermore, NME2 interacts with plakoglobin (γ-catenin), E-cadherin, and β-catenin and plakoglobin may increase its expression and stability [60].