Downregulation of NME1 expression may be the result of increased methylation of CpG islands at the transcription start site of the NME1 promoter: it has been reported that inhibitors of DNA methylation can elevate NME1 expression in tumor cells [70], and the protein arginine methyltransferase PRMT5 is directly involved in transcriptional repression of NME1 [71]. Here, PRMT5 is linked to neoplasm.