Finally, in the case of NSP15 endoribonuclease candidate drugs, dexamethasone produced gene expression signatures upregulated in pathways associated with viral infection response, such as ISG15 antiviral mechanism (NES = 1.82, p-adj = 3.17 × 10−3) and the antiviral mechanism by IFN-stimulated genes (NES = 1.59, p-adj = 1.20 × 10−2). Here, ISG15 is linked to viral infectious disease.