Remarkably, Myricetin [241,242], Apigenin [243,244] and its derivative Vitexin [206,207], Luteolin [226,228,245], Eriotyctiol [62,209], Taxifolin [216,246,247], Naringenin [248,249], EGCG [215,250,251], and Cyanidin [252,253,254] also decreased AKT phosphorylation and mTOR effectors in several cancer models, avoiding this feedback activation loop. The gene discussed is MTOR; the disease is cancer.