NOS2 and cancer: Along with GSH metabolism and the Warburg effect, there are enzymes and antioxidant factors that are largely modulated in cancer cells, such as Superoxide Dismutases (SODs), Catalase (CAT), NADP oxidases (NOXs), Nuclear Factor Erythroid 2-related Factor 2 (NRF2), COX-2, Nitric Oxide Synthase-2 (NOS2), and Hypoxia-Inducible Factor 1 alpha (HIF1α) [131,132,133,134].