Apigenin and Luteolin treatments in osteosarcoma models showed Forkhead box protein O1 (FOXO1) translocation and reduced Glucose-6-Phosphatase (G6Pc) mRNA levels, as well as Phosphoenolpyruvate Carboxykinase (PEPCK), CAT, and SOD [192,193]. This evidence concerns the gene G6PC1 and osteosarcoma.