VEGFA and malignant colon neoplasm: Another study showed that Kaempferol alone or in combination with 5-Fluorouracil (5-FU), a chemotherapeutic agent commonly used in colon cancer, reduces STAT3 phosphorylation in both parental and 5-FU chemo-resistant colon cancer cells, concomitant with a decrease in IL-8 and VEGF levels in 5-FU resistant cells [111].