High-risk iPSC-RPE from AMD donors had decreased expression of CD59 (0.8 fold, p = 0.09) and increased expression of C5AR1 (4.6 fold, p = 0.03) and IL-6 (4.8 fold, p = 0.05) compared to the low-risk group (Figure 5B). This evidence concerns the gene C5AR1 and age-related macular degeneration.