ESR1 and breast cancer: Furthermore, using a list of 10 genes that are known to be related to breast cancer biology—BRCA1, BRCA2, RASSF1, ESR1, TP53, PIK3CA, BRMS1, CDH1, CST6, PTEN (Table S6)—we examined whether UniReD could find any functional association with the proteins included in the signatures (Table 1).