Other interesting findings from the NGTS were: (i) frequent detection of RNF43 mutations in both dVIN and de-VIL, which have been previously associated with endometrial carcinoma [60], and (ii) detection of mutations in KEAP1, CDH1, PIK3R1, and POLE exclusively in de-VIL. The gene discussed is POLE; the disease is endometrial carcinoma.