Moreover, natural occurring D6.30 MVs in the follicle-stimulating hormone receptor, luteinizing hormone receptor, and thyroid-stimulating hormone receptor also display increased constitutive receptor activity and are consequently associated with familial spontaneous ovarian hyperstimulation syndrome [34], familial male-limited precocious puberty [35], and hyperfunctioning thyroid adenomas [36], respectively. Here, LHCGR is linked to Thyroid adenoma.