AGT and hypertensive disorder: In relation to hypertension, the activated IL-23/IL-17A immune axis has been found to cooperate with angiotensin II (Ang II)—the principal effector of the tissue renin-angiotensin system—in augmenting tissue inflammation and end-organ damage through mechanisms such as mobilization of immune cells to tissue, production of ROS, and tissue fibrosis (Figure 1) [37].