On the counterpart, among downregulated miRNAs, miR-200b is associated with clinical overall survival and M stage of RCC by targeting Laminin subunit alpha 4 (LAMA4), involved in angiogenesis and tumor metastasis, while miR-508 is associated with proliferation and invasion of RCC by targeting Zinc finger E-box-binding homeobox 1 (ZEB1) [64,65]. This evidence concerns the gene ZEB1 and renal cell carcinoma.