TWIST1 and familial pancreatic carcinoma: Low expression of Twist has also been observed in PANC-1, MiaPaCa-2, Capan-1, AsPC-1, and HPAF-2 cell lines of pancreatic cancer; still, induction of Twist expression occurs under hypoxic conditions, and this, seemingly, may take part in the invasive nature of tumors of pancreas [65].