There are several mitogenic growth factors and their ligands, which are overexpressed in pancreatic cancer, namely: EGF and EGFR (receptor of EGF), multiple EGFR binding ligands; FGF and FGFR; IGF and its receptor (IGFR); PDGF; VEGF [26]. The gene discussed is IGF1R; the disease is familial pancreatic carcinoma.