SMAD4 and cancer: (C) Neoantigens or mutated antigens derived from somatic point mutations in cancer cells (e.g., multiple myeloma-1 (MUM-1), cyclin dependent kinase 4 (CDK4), meiotic spindle formation protein 1 (ME1), actinin alpha 4 (ACTN4), HLA-A2 and mothers against decapentaplegic homolog 4 (SMAD4)) [100,101,102,103] are a category comprised of high immunogenic TAAs, since they are not expressed in normal cells and, thus tolerogenic mechanism do not occur.