The interleukin-18 (IL-18) gene (which encodes for a cytokine modulating brain homeostasis and neuroinflammation [88] and is linked to MS [89]) is more likely to be expressed from the maternal allele in the preoptic area of the hypothalamus and medial prefrontal cortex of females, suggesting the presence of a parent-driven epigenetic mechanism influencing gene expression in females, but not males [90]. The gene discussed is IL18; the disease is myeloid sarcoma.