Importantly, the in vivo data confirmed iRGD peptide penetration and extravasation via binding to αv integrins and showed NRP-1 colocalization after the i.v. infusion of the FAM-iRGD in ductal adenocarcinoma (PDAC) tumor bearing mice compared to the controls indicating NRP-1 dependent cellular internalization of the iRGD via the CendR pathway [31]. This evidence concerns the gene NRP1 and neoplasm.