For example, glioma cells and/or the BBB express abundant cell surface receptors, including mammary-derived growth inhibitor/fatty acid binding protein 3 (MDGI/FABP3) [8], transferrin [37,38], insulin [39,40,41,42,43,44], glucose transporters (GLUT-1) [45,46,47,48], large-neutral amino acid transporter LAT-1 [49,50,51,52,53], and the low-density lipoprotein receptor-related protein 1 (LRP-1) [54,55,56,57,58]. The gene discussed is LRP1; the disease is central nervous system cancer.