However, the expression of p-p65 and p-IκBα was significantly higher in S. pneumoniae-infected NLRP6−/− macrophages compared with WT macrophages (Figure 4B,D, * p < 0.05) while the expression of p-ERK1/2 was only markedly increased in NLRP6−/− macrophages at 15 min and 30 min post infection (Figure 4C). Here, MAPK3 is linked to infection.