CRP and mucopolysaccharidosis type 3A: Given that MPS IIIA patients are characterised by both neuro- and systemic inflammation [118], we cannot discount the possibility that there may also be other contaminating factors such as cytokines, e.g., C-reactive protein and other amine, peptide and lipid inflammatory mediators, which have also been shown to be potent inhibitors of surfactant [50,51].