We also observed the antiplatelet therapeutic clopidogrel, the anti-hypertension medications losartan, irbesartan and valsartan, an ACE inhibitor medication enalapril, blood lipid lowering atorvastatin, sulfonylurea-class glipizide and gliclazide among the DM patients, but mostly in DKD patients. This evidence concerns the gene ACE and diabetic kidney disease.