Moreover, for EQ-5D-5L_anxiety/depression (1.7 ± 0.9 in group A vs. 2.1 ± 1.1 in group B, p = 0.017) and regarding brain natriuretic peptide (BNP)-levels (483 ± 574 pg/mL in group A vs. 1480 ± 2444 pg/mL in group B, p < 0.001), there were significant differences between the staging groups. The gene discussed is NPPB; the disease is major depressive disorder.