CDKN2A and cancer: Following this cancer stem cell idea, Buchstaller et al., for example, compared the tumorigenic potential of two engrafted MPNST GEMMs and found that transplanted MPNST cells from Nf1+/−Ink4a/Arf−/− tumors encompassed a 10-fold higher fraction of cells with cancer-initiating potential than MPNST cells from Nf1+/− and Tp53+/− tumors [169].