As it has been reported that apoptosis-inducing function of NOXA is suppressed in constitutive NOXA-high expressing cancer cells—especially in hematopoietic cancers [53]—we considered that increasing the induction of NOXA by KLF4 in L-lines enhances the induction of apoptosis. Here, PMAIP1 is linked to hematopoietic and lymphoid cell neoplasm.