In particular, an increase in CD3+T and TIDC, and a reduction in putative immunosuppressive PMN-MDSC and Tregs, as testified by the increased CD8+T/Treg ratio, was observed in the spleen and tumor tissues of NeuT mice treated with CTX + Sl-IFN as compared to saline-treated controls. This evidence concerns the gene IFNA1 and neoplasm.