PROM1 and neoplasm: In vitro, GSCs have a high regenerative ability and the capacity to differentiate into glial or neuronal cells [29], expressing specific neural markers, such as CD133, A2B5, L1CAM, SOX2, CXCR4, CD15, CD44, Integrin α6, CD36 [30,31,32,33,34], and generate heterogeneous populations that participate in tumor propagation, drug resistance, and relapse [35].