CHRNA7 and major depressive disorder: The rostromedial tegmental (RMTg) nucleus, which contributes to monoaminergic responses to stressing events and is involved in depression, receives cholinergic inputs from the laterodorsal and pedunculopontine tegmental nuclei that activate presynaptic α7 nAChRs, thus finally increasing Glu release in the lateral habenula (LHb).