Similarly, Zhang et al. have further demonstrated, utilising both global databases and immunohistochemical staining, that EPLIN expression was reduced in metastatic prostate and colon tumours and in lymph node metastasis of prostate, colorectal, breast and squamous cell carcinoma of the head and neck (SCCHN) cancer [6]. This evidence concerns the gene LIMA1 and metastatic malignant neoplasm in the lymph nodes.