NAFLD and its progressive forms have a strong inherited component, and variants in genes regulating lipid handling, including patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2) and membrane bound O-acyltransferase domain-containing 7 (MBOAT7), predispose to NAFLD development and progression towards end-stage conditions [5,6]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.