SORT1 and hepatocellular carcinoma: Therefore, in attempt to decipher the role of this locus in lipid handling, cardiovascular protection, and HCC predisposition, we demonstrated that patients who carry the rs599839 G allele showed higher hepatic mRNA levels of SORT1, CELSR2 and PSRC1. It has also been previously reported that rs599839 variant strongly correlated with SORT1, PSRC1 and CELSR2 transcript levels in human liver [12,40,41], and we further reinforced this data with transcriptional studies and network analysis by STRING.