In this study, we examined the impact of the rs599839 A > G variant which is localized in the genetic cluster of CELSR2-PSRC1-SORT1 on metabolic phenotypes and liver damage in a large cohort of histologically characterized NAFLD patients, in individuals from UKKBC and in HCC patients from TCGA. Here, SORT1 is linked to metabolic dysfunction-associated steatotic liver disease.