To determine whether the epidemiological association between the rs599839 variant and protection against CAD and higher risk to develop HCC in NAFLD patients may be mediated by the modulation of transcriptional activity at this locus, we examined the hepatic expression of PSRC1, SORT1 and CELSR2 in a subset of patients belonging to the Overall cohort of whom transcriptomic data was available (n = 125). The gene discussed is SORT1; the disease is metabolic dysfunction-associated steatotic liver disease.