Notably, we demonstrated that the enhanced hepatic expression of SORT1 mainly affected circulating lipid profiles, lipoprotein turnover and release, while PSRC1 expression most strongly impacted on genes implicated in cell proliferation and survival thus possibly explaining the opposite effect of the rs599838 variation which protects against cardiovascular complications and as one predisposes to HCC, respectively. This evidence concerns the gene PSRC1 and hepatocellular carcinoma.