PNPLA3 and type 2 diabetes mellitus: At multivariate generalized linear models, we found that the G minor allele was associated with reduced TC (beta: −0.15; 95% c.i. −0.25–−0.04; p = 0.005), LDL cholesterol (beta: −0.20; 95% c.i. −0.30–−0.10; p < 0.0001) and with increased HDL cholesterol (beta: 0.07; 95% c.i. 0.03–0.10; p = 0.0003), after adjustment for sex, age, body mass index (BMI), type 2 diabetes (T2D), PNPLA3 I148M, TM6SF2 E167K and MBOAT7 rs641738 variants by using an additive model (Table 2).