Since the rs599839 variant is located at 500 b downstream of the 3′ untranslated region (UTR) of PSRC1 gene, which is required for the congress of chromosomes at the metaphase plate and for normal rate of chromosomal segregation during anaphase, we next sought to examine whether the rs599839 variation may affect the risk to develop HCC in NAFLD patients. The gene discussed is PSRC1; the disease is metabolic dysfunction-associated steatotic liver disease.