In details, the CELSR2 gene encodes a non-classic type of cadherin involved in cell adhesion [15], while the PSRC1 gene product participates to microtubule destabilization and spindle assembly [16] and its overexpression has been detected in tumor liver tissues and in hepatoma cells, where it is associated with HCC recurrence after resection [17]. Here, CELSR2 is linked to hepatocellular carcinoma.