However, despite the epidemiological association between NAFLD and cardiovascular disease, we previously shown that genetic variants impacting on lipoprotein secretion and determining hepatocellular lipid retention, such as loss-of-function variants in TM6SF2, predispose to progressive NAFLD despite offering protection against cardiovascular disease [10]. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.