In 229 overall RCCs, the factors significantly associated with CCS or RFS in univariate analysis were age (CSS, P < 0.001; RFS, P = 0.005), tumor size (CSS, P < 0.001; RFS, P < 0.001), tumor stage (CSS, P < 0.001; RFS, P < 0.001), lymph node metastasis (CSS, P = 0.615; RFS, P < 0.001), histologic nuclear grade (CSS, overall P = 0.032; RFS, overall P = 0.008), tumor necrosis (CSS, P < 0.001; RFS, P = 0.004), and IL13Rα2-positivity (CSS, P = 0.002; RFS, P < 0.001) (Table 2). This evidence concerns the gene IL13RA2 and metastatic malignant neoplasm in the lymph nodes.