The Kaplan–Meier survival curves for CSS and RFS according to IL13Rα2-positivity in overall RCC are presented in Figure 1C. In 201 CCRCCs, the factors significantly associated with CCS or RFS in univariate analysis were age (CSS, P = 0.004; RFS, P = 0.012), tumor size (CSS, P < 0.001; RFS, P < 0.001), tumor stage (CSS, P < 0.001; RFS, P < 0.001), lymph node metastasis (CSS, P = 0.721; RFS, P = 0.011), histologic nuclear grade (CSS, overall P = 0.170; RFS, overall P = 0.028), tumor necrosis (CSS, P = 0.005; RFS, P = 0.063), and IL13Rα2-positivity (CSS, P = 0.003; RFS, P < 0.001) (Table 2). Here, IL13RA2 is linked to metastatic malignant neoplasm in the lymph nodes.