CD4 and ovarian carcinoma: In particular, the density of granzyme B+ CD8+ cytotoxic T cells (CD8_4) was significantly higher in LTS than in STS, expanding the prior knowledge that CD3+, CD4+, and CD8+ tumor-infiltrating lymphocytes are associated with positive outcomes in ovarian cancer [72,73,74,75] and highlighting that only a particular subtype of activated T cells (granzyme B+) is associated with good clinical outcomes in ovarian cancer.