In the epithelial compartment of HGSC tumors, we identified expression levels of several genes involved in the migration and invasion of cancer cells correlated with CD73_1, CD73_2, and CD31 densities and with poor survival, suggesting that these genes regulate the metastatic potential of cancer cells in a paracrine manner; these genes included PARD6B, S100A10, SLURP1, and SPINT1. In addition, we demonstrated that ovarian cancer cell–derived ITIH5, TACSTD2, and WFDC2 expression levels were negatively correlated with granzyme B+ CD8+ cytotoxic T cell (CD8_4) densities. The gene discussed is SPINT1; the disease is cancer.