Among them, granzyme B+ CD8+ cytotoxic T cells (CD8_4) had significantly more interactions with multiple tumor cell subtypes (tu_1, tu_2, tu_3, and tu_5) in LTS than in STS (Figure 6A), suggesting increased interactions between CD8 cytotoxic cells and multiple subtypes of tumor cells in LTS. The gene discussed is CD8A; the disease is neoplasm.