TNC and neoplasm: These results are supported by our research showing that CAF subtypes, CD73_1 and CD73_2, express genes, such as ANGPTL2, TNC, TGFB1, FN1, BMPR1B, and LRRC32, promote tumor progression, angiogenesis, and extracellular matrix remodeling [60,61,67,69,70,87,88].