In contrast to more CD8_4–tumor cell interactions in LTS than in STS, CD73mid cell (CD73_2) had significantly fewer interactions with 17 cell subtypes, including CD73_1, CD31, macrophages and monocytes (ma_1, ma_2, ma_4, ma_5, ma_8, ma_9), stromal cells (s_1, s_2), T cells (CD4_5, CD8_2), and tumor cells (tu_1, tu_3, tu_4, tu_5, tu_6), than in STS, suggesting that when there are more CD73_2 cells in the tumor microenvironment, most of them are surrounded by macrophages and tumor cells in STS. Here, CD8A is linked to telomere syndrome.