TNF and metabolic dysfunction-associated steatotic liver disease: Indeed, patients with NAFLD were shown to have increased markers of systemic inflammation including interleukin 6, high sensitivity CRP, interleukin 1b, tumor necrosis factor [TNF]-α, chemokine [C-C motif] ligand 3, soluble intracellular adhesion molecule 1, and macrophage phenotype 1/2 ratio [M1/M2] [111,115,116,117,118].