Five compounds, i.e., AKT-Inhibitor-VIII, vinblastine, MK-2206, roscovitine, and nutlin-3a, were significantly enriched for high energy in four cancer types (UVM, STAD, LAML, and HNSC) with high EMT and inhibited tumor aggressiveness-related tumorigenicity. This evidence concerns the gene AKT1 and cancer.