TNF and neoplasm: Furthermore, in this model TNF deficiency in Mlys+ myeloid cells was associated with enhanced hepatic tumor progression, including such antitumor effects of myeloid-cell-derived TNF as direct tumor cell apoptosis and a reduced expression of immunosuppressive molecules like TGF-β, IL-10, iNOS, IL-33, and heme oxygenase-1 [30].