LTBR and neoplasm: In addition, LTα production by effector T cells was shown to potentiate an antitumor response in a B16F10 melanoma pulmonary metastasis model [45], while blocking LTβR with a neutralizing monoclonal antibody decreased effector T-cell cytotoxicity in vitro [46], suggesting that LTαβ–LTβR interaction was crucial for the cytotoxic cell activation required for tumor regression.