The concept of cancer-cell-induced remodeling of the microenvironment as a mechanism of cancer progression was recently reinforced with the discovery of reciprocal interaction between Myc-driven lymphoma cells expressing vascular endothelial growth factor C (VEGFC) and LTα2β1 on one hand and the corresponding VEGF receptor-3 and LTβR on high endothelial venules on the other. The gene discussed is VEGFC; the disease is lymphoma.