LTβR signaling may also modulate the leukemic microenvironment: inactivation of LTβR results in a significant delay in leukemia onset in TEL-JAK2 mice, which spontaneously develop T-cell leukemia, presumably due to the loss of LTβR signaling in thymic stromal cells [99]. The gene discussed is LTBR; the disease is T-cell leukemia.