Studies that addressed the relationship between TNF polymorphisms and hematopoietic malignancies suggested that the TNF rs1799724 C > T polymorphism may be a causative factor for multiple myeloma [188], while TNF rs1800629 is a risk factor for diffuse large B-cell lymphoma in the Caucasian population [189] and non-Hodgkin lymphoma among Caucasians and Africans [189,190]. This evidence concerns the gene TNF and non-Hodgkin lymphoma.