In another lung metastasis mouse model, renal adenocarcinoma (Renca) inoculation into TNFR1-deficient mice displayed spontaneous regression of metastasis foci as compared with wild-type (WT) mice, indicating that signal transduction via TNFR1 supports tumor neovascularization and promotes lung metastasis [21]. Here, TNFRSF1A is linked to neoplasm.