LTBR and neoplasm: Moreover, a short-term treatment of mice, predisposed to prostate cancer, with the fusion protein consisting of the extracellular domain of LTβR and Fc reduced the size of the primary tumors and completely prevented metastasis later in life through the expansion of T cells specific to tumor antigens [138], suggesting the pathogenic role of lymphotoxin-mediated LTβR signaling in cancer.