FOXP3 and neoplasm: The 10 identified metaclusters were divided into three main groups: (i) senescent and terminally differentiated (metaclusters 6,8,4) or non-tumour responsive (metaclusters 2,5,9,10) (~76.15 ± 9.45%), (ii) exhausted (metacluster 7; 2.71 ± 2.03%) and (iii) Foxp3+ regulatory (~18.53 ± 8.78%).