KAT2B and malignant colon neoplasm: Consistent with this, the Gcn5/PCAF family, which acetylates histone H3K9, was shown to be highly stimulated by ACLY-derived acetyl-CoA, but less so by ACSS2-derived acetyl-CoA, in subcutaneous white adipose tissue or HCT116 colon cancer cells [41,103].