CREBBP and obesity due to melanocortin 4 receptor deficiency: The decreased CBP levels that occur with aging in some tissues may contribute to aging-induced pathology because haploinsufficiency of CBP due to hemizygosity results in human Rubinstein-Taybi syndrome, an autosomal dominant disorder characterized by many disease phenotypes including intellectual disability, shortness of stature, obesity, and heart and kidney defects [181].