CD47 and neoplasm: Table 2 shows the association between CD47 expression and the clinicopathologic factors. In all cases, a positive CD47 expression was significantly correlated with lymphatic invasion (p = 0.018, chi-square test), perineural invasion (p = 0.024, chi-square test), tumor budding (p = 0.009, chi-square test), the pN stage (p = 0.022, chi-square test), and the AJCC stage (p = 0.027, chi-square test).