STAT3 and neoplasm: In addition to the previously mentioned crucial role of the NF-κB protein in inflammation, other molecular inflammatory molecules such as cytokines, chemokines, inflammatory enzymes (cyclooxygenase (COX)-2, matrix metalloproteinases), anti-apoptotic proteins, oncogenes, and transcription factors (CREB, AP-1, STAT3) are involved in the regulation of tumor cell proliferation, transformation, and survival [88].