HDAC8 and idiopathic pulmonary arterial hypertension: This excitement is further bolstered by the observation that mRNA or/and protein levels of HDACs are increased in PH, including human lung homogenates of PH patients (HDAC1, HDAC4 and HDAC5) [38], pulmonary artery ECs from PH patients (HDAC4 andHDAC5) [39], pulmonary artery adventitial fibroblasts from PH calves(HDAC1, HDAC2 and HDAC3) [14], and pulmonary arteries and pulmonary artery adventitial fibroblasts from IPAH patients (HDAC1 and HDAC8) [40].