This selectivity has been partly confirmed in a recent study on mice [16]; specifically, in a model of experimental acute pancreatitis, ablation of PRX-I in the pancreas with mild inflammation and low PRX-I expression showed no impact on pancreatic cells, whereas PRX-I inactivation in the pancreas with severe inflammation and high PRX-I expression exhibited protective effects on pancreatic cells [16]. Here, PRDX1 is linked to acute pancreatitis.