To unravel the role of PGC1α in lung cancer, we first selected the ideal lung cancer cell lines, which showed either high or low levels of PGC1α, and we found that PGC1α levels are downregulated in lung cancer cells compared to Beas-2b, normal bronchial epithelial cells (Figure S1A,B). The gene discussed is PPARGC1A; the disease is lung cancer.