NDRG1 and myeloid sarcoma: Indeed, it was shown that promoters of genes such as BCL2L2 and NDRG1, both genes that regulate oligodendrocyte survival, are hypermethylated in normal appearing white matter of MS patients, and that consequently the proteins are less expressed, which in turn leads to accelerated oligodendrocyte apoptosis, accompanied by less efficient remyelination [41].