Full-length TDP-43, the 45 kDa form, and ubiquitylated TDP-43 have been found in the soluble, inclusion-free fraction of brain tissues from ALS-TDP patients, which indicates that mislocalization of TDP-43, preceding the aggregation, play a role in the early pathogenesis of ALS [88]. Here, TARDBP is linked to amyotrophic lateral sclerosis.